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| Moura Lima,Eleonidas; Ferreira Leal,Mariana; de Arruda Cardoso Smith,Marília; Rodríguez Burbano,Rommel; Pimentel de Assumpção,Paulo; Bello,Maria Jose; Rey,Juan Antonio; Ferreira de Lima,Francinaldo; Casartelli,Cacilda. |
| Gastric cancer is one of the most common malignancies. DNA methylation is implicated in DNA mismatch repair genes deficiency. In the present study, we evaluated the methylation status of MLH1, MSH2, MSH6 and PMS2 in 20 diffuse- and 26 intestinal-type gastric cancer samples and 20 normal gastric mucosal of gastric cancer patients from Northern Brazil. We found that none of the nonneoplastic samples showed methylation of any gene promoter and 50% of gastric cancer samples showed at least one methylated gene promoter. Methylation frequencies of MLH1, MSH2, MSH6 and PMS2 promoter were 21.74%, 17.39%, 0% and 28.26% respectively in gastric cancer samples. MLH1 and PMS2 methylation were associated with neoplastic samples compared to nonneoplastic ones. PMS2... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gastric cancer; MLH1; MSH2; MSH6; PMS2. |
| Ano: 2008 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000300004 |
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| Alves dos Santos,Raquel; Cabral,Teresinha Rosa; Cabral,Isabel Rosa; Greggi Antunes,Lusânia Maria; Pontes Andrade,Cristiane; Cerqueira dos Santos Cardoso,Plínio; de Oliveira Bahia,Marcelo; Pessoa,Claudia; Martins do Nascimento,José Luis; Rodríguez Burbano,Rommel; Satie Takahashi,Catarina. |
| Physalis angulata L (Solanaceae) is a medicinal plant from North of Brazil, whose different extracts and infusions are commonly used in the popular medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatism. However, the genotoxic effects of P. angulata on human cells is not well known. The main purpose of the present study was to evaluate the in vitro genotoxic effects of aqueous extract of P. angulata using the comet assay and the micronucleus assay in human lymphocytes provided from 6 healthy donors. Treatments with P. angulata extracts were performed in vitro in order to access the extent of DNA damage. The comet assay has shown that treatments with P. angulata at 0.5, 1.0, 2.0, 3.0 and 6.0 μg/mL in culture medium were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P. angulata; Micronuclei; Comet assay. |
| Ano: 2008 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200005 |
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